Periodical literature
Quantitative electroencephalogram in Parkinson's disease with white matter lesions
Date：
2022-01-21
YU Yue-hua1 , ZHAO De-hao2 , DING Ping2 , ZHANG Li2 , WEI Wen-shi2 . (1.Department of Neurology, Qingpu Branch,
Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China; 2.Department of Neurology, East China Hospital Affiliated to Fudan University; Cognitive impairment center of East China Hospital Affiliated to Fudan University, Shanghai 200040, China.)
[ Abstract ] Objective: To analyze the relationship between the degree of cerebral white matter lesions and quantitative EEG in patients with
Parkinson's disease. Methods: According to Fazekas classification, 31 PD patients with WML were divided into mild WML group and moderate severe WML group. The cognitive function and quantitative EEG indexes were compared between the two groups, and the correlation between the severity of white matter lesions and EEG changes was analyzed. Results: Compared with the mild WML the group, the overall cognitive level (MoCA) of patients in the moderate to serve WML group decreased (P=0.013)；Analysis of QEEG data between the two groups found that the moderate to serve WML group had a lower relative alpha band powers than the mild WML group in C3 (left central area), P3(Left parietal region) and T5(left posterior temporal) (P <0.05 ); The relative theta band powers was increased in P3 (Left parietal region), T4 (right middle temporal) and O1 (left occipital region) (P <0.05); and the ratio of (α + β / θ + δ) was reduced in F7 (left front temporal) (P <0.05). For the analysis of the correlation between WML severity, clinical characteristics and QEEG activity in PD patients, the PD patients age, motor symptom severity, vascular risk factors and statistically significant QEEG indicators into the Logistic regression analysis model, the results showed that the decrease of the relative alpha band powers in T5 (left posterior temporal) and hypertension are associated with WML severity in PD (P <0.05). Conclusion: Decrease of a band relative energy of T5 (left posterior temporal) has certain clinical value in the identification of PD patients with moderate severe WML.
[ Key words ] Parkinson’s disease; leukoencephalopathy; cognitive function; Quantitative electroencephalogram