Periodical literature
A Case Report of psychotic symptoms as clinical presentation of thiamine deficiency in an
Alzheimer's disease patient
Date：
2022-01-21
ZHOU Yi-ping, WEI Wen-shi, (Huadong Hospital Affiliated to Fudan University, Department of Neurology, Center of Cogntive Disorder , Shanghai 200040, China.)
[Abstract] The incidence of thiamine deficiency (TD) induced by non-alcoholic diseases is very low, which is often neglected clinically,
resulting in Wernicke encephalopathy (WE) or Korsakoff syndrome caused by the delay in the treatment of this disease. Few cases have been
reported the association between the exacerbation of the psychiatric symptoms of Alzheimer's disease (AD) patient and thiamine deficiency. An
old man with AD visited our clinic because of acute deterioration in psychological symptoms of dementia (BPSD), with a decrease in food intake lasting more than 1 month, symptoms were improved significantly after thiamine administration. It is recommended that the treatment with TD can be started in any situation where thiamine deficiency is suspected. The potential benefits brought by it far outweigh the risks of no treatment. Meanwhile, it is recommended that therapeutic administration of thiamine be commenced in any case where thiamine deficiency is suspected, the potential benefits to a patient with possible thiamine deficiency far outweigh the risks of not treating.
[Keywords] thiamine; BPSD; wernicke encephalopathy; case report