Periodical literature
Progressive supranuclear palsy with mimic normal pressure hydrocephalus: A case report and
research progress
Date：
2022-01-21
LIU Ying, YANG Fu-xia, GU Chun-hui, WEI Wen-shi. (Cognitive Disorder Center, Department of Neurology, Huadong
Hospital, Shanghai 200040, China.)
[ Abstract ] Objective: To demonstrate a PSP patient which appeared iNPH-like magnetic resonance imaging (MRI) features. Methods:
Analyze the diagnosis and treatment of a PSP patient in our hospital, and review the relevant research progress. Results: This patient presented
with dyskinesia, stiff limbs, cognitive impairment, dysphagia and dyslalia; The MRI features conclude midbrain atrophy and signal changes．
Midbrain atrophy presents “morning glory sign” in axial plane and “hummingbird sign” (HBS)in the median sagittal plane. The third and
fourth ventricles were enlarged, the Evan’s index>0.34. Cerebrospinal fluid (CSF) tap/shunt treatment in this case resulted in short-term benefits
but subsequent deterioration ensued within one year. And the effect of large doses of dopa serazine was not good. Conclusion: This study
demonstrated that some PSP patients develop iNPH-like MRI features, suggesting the presence of iNPH-like features in clinical spectrum of PSP. An awareness that PSP can mimic the clinical symptoms of iNPH may help to avoid invasive cerebrospinal fluid shunting procedures.
[Key words] idiopathic normal pressure hydrocephalus; Progressive supranuclear palsy; magnetic resonance imaging