Periodical literature
The Correlative Factors Affecting Plasma D-dimer Levels in Elderly Psychiatric Inpatients
Date：
2022-01-21
ZHOU Yi-rong1,2 , ZHANG Wei1,2 , ZHANG Ren-li1,2 , FEI Jie1,2 , HUANG Jing-wen1,2 , LIU Yan1,2 , WANG Jing-hua1,2 .
(1.Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School
of Medicine, Shanghai 200030, China; 2.Alzheimer's Disease and Related Disorders Center, Shanghai Jiao Tong
University, Shanghai, China.)
[ Abstract ] Objective: To explore the related factors affecting the increase of D-dimer in elderly psychiatric inpatients, and to provide
references for formulating effective treatment and nursing measures. Methods: A retrospective analysis of the clinical data and biochemical test results of 197 patients hospitalized in the Geriatric Psychiatric Department of Shanghai Mental Health Center from November 2017 to August 2018. The D-dimerization in the blood of the patients was detected by a fluorescence immunoassay instrument. According to the positive result of plasma D-dimer ≥ 600ng/ml, it was divided into two groups: D-dimer elevated group and D-dimer normal group. The differences in general data and biochemical examinations between the two groups were compared. Single factor analysis and binary logistic regression analysis were used to screen out the relevant factors affecting the increase of D-dimer. Results: There were 84 cases in the elevated D-dimer group and 113 cases in the normal D-dimer group. The independent sample test showed age, average daily bedtime, C-reactive protein (CRP), and urea nitrogen between the two groups. The difference was statistically significant (P values were 0.000, 0.045, 0.008, 0.034), and the χ2 test showed that there was a statistically significant difference in the history of diabetes between the two groups. Binary logistic regression analysis showed that age, diabetes history, and elevated CRP were the main risk factors that affected the elevation of D-dimer in elderly psychiatric patients. Conclusion: Diabetes history and infection are the main risk factors affecting the increase of D-dimer in elderly psychiatric patients.
[ Keyword ] D-dimer; Elderly patients; diabetes mellitus; infection