Li Zhe-yu1, Li Kai-cheng2, Zeng Qing-ze2, Chen Yan-xing1, Zhang Min-ming2

(1. Department of Neurology, 2nd Affiliated Hospital of Zhejiang University School of Medicine;2. Department of Radiology, 2nd Affiliated Hospital of Zhejiang University School of Medicine)

Abstract    Alzheimer’s disease (AD) can be classified into early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD), depending on the age of disease onset. Thereinto, EOAD shows a rapid progression after onset and thus requires earlier diagnosis. Identification of differences in clinical manifestations, including the imaging features, would be important in early detection of the two subtypes. Although EOAD patients can be confirmed with special symptoms, including visuo-spatial dysfunctions, there still remains other overlaps between EOAD and LOAD which requires an early and accurate diagnosis. This review provides an overview of two subtypes and tries to provide some references for diagnosis, especially for EOAD.

李喆宇1  李凯程2  曾庆泽2  陈艳杏1  张敏鸣2

（1. 浙江大学医学院附属第二医院神经内科；2. 浙江大学医学院附属第二医院放射科）

2019年10月 第2卷 第四期  文章编号  2096-5516(2019)04-0537-07

摘要目的阿尔茨海默病（AD）是最常见的痴呆类型，临床上主要表现为进行性认知功能障碍。根据发病年龄可以将AD进一步分为早发型AD（EOAD）与晚发型AD（LOAD），两者的发病机制、临床表现及进展方式均有所不同。其中，EOAD临床进展快预后差，早期诊断十分关键。尽管视空间功能障碍等特异性症状能在一定程度上支持EOAD的诊断，但由于EOAD和LOAD在许多方面仍然相似，临床诊断及鉴别诊断仍存在较大困难。本文对以上两种AD亚型的神经心理学及神经影像学特征进行综述，以期为该病的诊断与治疗提供一定参考。